\n\nResults: Due to an acute bleeding situation in 143 patients, 7.9 +/- 5.8 units of packed red blood cells, 9.5 +/- 6.1units of fresh frozen plasma, 1740 +/- 1860 IU PPSB (Prothrombin-Proconvertin-Stuart Factor-Antihemophilic Factor B), 5.6 +/- 4 g fibrinogen, and 7.9 +/- 7.6 units of platelets were administered. A re-thoracotomy was necessary, despite maximal procoagulant therapy, in 55% of patients. The in-hospital mortality was 36% (51/2453 = 2%). Thrombotic complications occurred with a frequency ALK activation of 16% (mesenteric infarction, n = 9; stroke/transient ischemic attack, n = 3; myocardial infarction, n = 3; other, n = 8).\n\nConclusion: The proof of direct causality of the events in relation to the

administration of FVIIa is difficult because the temporal and therapeutic relationships with concomitant vasoconstrictive and procoagulant therapies were not obvious. However,

there remains a suspicion that a higher rate of mesenteric infarctions may be provoked by the administration of FVIIa.”
“OBJECTIVE: A number of researchers have suggested the use of sodium hyaluronate carboxymethyl cellulose (HA-CMC) membrane for preventing postoperative adhesion. This study evaluated the anti-adhesive effect and safety of a newly developed HA-CMC solution in thyroidectomy.\n\nMETHODS: Seventy-four patients who underwent thyroidectomy AEB071 were prospectively randomized. In the study group of 38 patients, 5 mL HA-CMC solution was applied to the operative field after thyroidectomy. The subjects were asked about adhesive symptoms using a four-item questionnaire at 2 weeks, 2 months and 6 months after surgery. In addition, three items on the appearance of neck wrinkles and scars were evaluated by a physician. Each item was scored BMS345541 from 0 to 10.\n\nRESULTS: The mean ( standard deviation) total adhesion score at each visit was 15.22 +/- 8.99, 10.42 +/- 8.41, and 7.24 +/- 5.83 for the control group and 19.29 +/-

9.71, 9.46 +/- 5.71, and 6.03 +/- 4.32 for the study group. Total adhesion scores for both groups decreased with time (p<0.001), but no significant differences were noted between the two groups (p>0.066). There were no complications related to the HA-CMC solution.\n\nCONCLUSION: The HA-CMC solution did not decrease subjective or objective postoperative adhesion in patients undergoing thyroid surgery, although it was biologically safe. [Asian J Surg 2010;33(425-30]“
“Background: Optimal dosage for growth hormone (GH) therapy in short, prepubertal children born small for gestational age (SGA) is controversial. Methods: SGA OPTIMIS (NCT00249821) is a multicenter, open-label, parallel-group, pilot study of short children born SGA who had received recombinant human GH (r-hGH) (57 mu g/kg/day) for 3 years. Children were randomized 1: 1 to receive either 57 or 35 mu g/kg/day r-hGH during year 4. The primary endpoint was height gain during year 4.